ea0065oc1.2 | Metabolism and Obesity | SFEBES2019
Green Charlotte
, Pramfalk Camilla
, Charlton Catriona
, Gunn Pippa
, Cornfield Thomas
, Pavalides Michael
, Karpe Fredrik
, Hodson Leanne
Background and Aim: Hepatic de novo lipogenesis (DNL) has been implicated in the development of non-alcoholic fatty liver disease (NAFLD). Supplementation with the omega-3 fatty acids (FA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) decreases intrahepatic triacylglycerol (IHTAG) and plasma TAG concentrations, which is suggested to be mediated through changes in hepatic DNL. We investigated the effects of omega-3 FA supplementation on intrahepatic DNL an...